Buy Tri-Luma Cream (Fluocinolone/Hydroquinone/Tretinoin) Online From Medications Canada.

Tri-Luma Cream (fluocinolone/hydroquinone/tretinoin)

Indications and Usage

Tri-Luma Cream is a combination of fluocinolone acetonide, hydroquinone, and tretinoin. Fluocinolone acetonide is a corticosteroid, hydroquinone inhibits melanin synthesis, and tretinoin is a retinoid. This cream is indicated for the short-term treatment of moderate to severe melasma on the face, and it should be used alongside measures for sun avoidance, including the regular use of sunscreens.

Limitations of Use

Tri-Luma Cream is not intended for long-term maintenance therapy for melasma. Once control is achieved with Tri-Luma Cream, some patients may transition to alternative treatments instead of continuing with the triple therapy provided by Tri-Luma Cream. Discontinuation of Tri-Luma Cream often leads to the recurrence of melasma. The safety and effectiveness of Tri-Luma Cream in individuals with Fitzpatrick Skin Types V and VI have not been investigated. There is a possibility of excessive bleaching, which may result in undesirable cosmetic outcomes, particularly in individuals with darker skin tones. Additionally, Tri-Luma Cream has not been evaluated for its safety and efficacy in treating hyperpigmentation conditions other than melasma on the face. Clinical trials excluded pregnant and lactating women, and women of childbearing age were required to use contraception. Therefore, the safety and effectiveness of Tri-Luma Cream for pregnant women and nursing mothers have not been determined.

Dosage and Administration

• Spread a thin layer of Tri-Luma Cream over the affected region once per day, ensuring application at least 30 minutes before bedtime.
• Cleanse the face and neck gently with a mild cleanser, then rinse and pat the skin dry before applying Tri-Luma Cream to areas affected by melasma, extending about 1/2 inch onto the surrounding normal skin. Massage gently and evenly into the skin. Discontinue treatment once melasma is under control.
• During daylight hours, use a sunscreen with an SPF of 30 and wear protective clothing, while avoiding direct sunlight exposure. Moisturizers and cosmetics may be used during the day.
• Tri-Luma Cream is solely for topical application and should not be taken orally, applied to the eyes, or used intravaginally.

Tri-luma Ingredients

The active ingredients in Tri-Luma Cream are fluocinolone acetonide, hydroquinone, and tretinoin. Inactive ingredients include butylated hydroxytoluene, cetyl alcohol, citric acid anhydrous, glycerin, glyceryl stearate, magnesium aluminum silicate, methyl gluceth-10, methylparaben, PEG-100 stearate, propylparaben, purified water, sodium metabisulfite, stearic acid, and stearyl alcohol. 

Contraindications

Tri-Luma Cream is contraindicated in individuals with a history of hypersensitivity to this product or any of its components.

Warnings and Precautions

• Hypersensitivity
• Exogenous Ochronosis
• Effects of Endocrine System
• Cutaneous Reactions

Tri-Luma Cream Side Effects 

Tri-Luma Cream side effects may include redness, dryness, peeling, itching, or a burning feeling. Some people may also develop acne. These Tri Luma side effects are often mild and may go away with time. 

Let your doctor know if any of these Tri-Luma Cream side effects are bothersome or don’t improve. 

In rare cases, Tri Luma side effects can be serious. These include severe allergic reactions. Stop using the cream and seek medical help right away if you notice swelling of your face, lips, tongue, or throat. Trouble breathing, rash, hives, or severe itching are also signs of an allergic reaction. 

Tri-Luma Cream may cause blue-black skin discoloration. This is a rare but serious side effect. Stop using the cream and contact your doctor if your skin darkens like this. 

Some ingredients in the cream can enter your bloodstream. This may affect your adrenal glands. Your doctor may monitor you with blood tests. These effects may not have clear symptoms. 

The cream may cause skin irritation, especially in sensitive areas. Stop using Tri-Luma Cream if you develop blistering, crusting, swelling, or severe burning. Also stop using it if the cream irritates your eyes, nose, or mouth. 

This is not a full list of Tri Luma side effects. Ask your doctor or pharmacist for a complete list. 

Storage and Handling

Keep tightly closed. Store in a refrigerator, 2˚ – 8˚C (36˚ – 46˚F). Protect from freezing.

FAQs

What is the most important information I should know about Tri-Luma Cream?

Using Tri-Luma Cream during pregnancy can lead to birth defects or fetal death. This risk is higher, especially during the first trimester. Inform your doctor if you’re pregnant or planning to conceive. If you become pregnant while using Tri-Luma Cream, inform your doctor immediately.

Who should not use Tri-Luma Cream?

Do not use Tri-Luma Cream if you are allergic to it or any of the ingredients in Tri-Luma Cream.

What should I tell my doctor before using Tri-Luma Cream?

Before starting Tri-Luma Cream, inform your doctor if you:

• Have an allergy to sulfites.
• Have any other medical conditions.
• Are currently pregnant or planning to conceive.
• Are breastfeeding or intend to breastfeed. It’s uncertain whether Tri-Luma Cream passes into breast milk. Avoid direct contact between treated areas and your baby’s skin.

Additionally, disclose all medications you’re taking, including prescriptions, over-the-counter drugs, vitamins, herbal supplements, and skincare products.

What should I avoid while using Tri-Luma Cream?

• Refrain from exposure to sunlight, sunlamps, tanning beds, and ultraviolet light while using Tri-Luma Cream.
• Apply sunscreen with an SPF of 30 or higher. If exposed to sunlight, wear protective clothing such as a wide-brimmed hat to shield the treated areas.
• Even minimal sunlight exposure can exacerbate melasma. It’s important to continue sun avoidance, sunscreen use, and protective clothing post-treatment with Tri-Luma Cream.
• Women should avoid hormonal birth control methods as they may worsen melasma. Discuss alternative contraceptive options with your doctor.
• Extreme temperatures, both hot and cold, may cause irritation to the skin treated with Tri-Luma. Consult your doctor for advice on managing skin irritation.

How much can I save when purchasing Tri-Luma Cream from a Canadian pharmacy versus U.S. prices?   

Purchasing Tri-Luma Cream from a Canadian pharmacy can lead to major savings. At Medications Canada, the 0.01/4/0.05% is priced at $235.00 for 30g cream, compared to about $271.87 in the U.S. You save up to 13.56%. 

How long does it take to receive Tri-Luma Cream when ordering online?   

It takes approximately 2 to 4 weeks to ship Tri-Luma Cream after it leaves the pharmacy. 

Is a prescription required to buy Tri-Luma Cream online?   

Yes, a valid prescription is required to buy Tri-Luma Cream online. 

What payment options are available for purchasing Tri-Luma Cream online?   

We take payments by personal check, certified check, international money order, and e-check.   

What is the refund or return policy for Tri-Luma Cream bought online?   

Pharmaceutical laws and safety rules prevent us from accepting returns or issuing refunds for Tri-Luma Cream bought online. Always consult your doctor before ordering. 

Is Tri-Luma Cream available over the counter?   

Tri-Luma Cream is not available over the counter because it needs to be used under a doctor’s supervision. Due to the risk of serious side effects, like trouble breathing, a valid prescription is required to ensure safe use. 

References

Triluma.com. (2023). Highlights of Prescribing Information

FDA.gov. (2014). Prescribing Information

Drugs.com. (2025). Prices, Coupons, Copay Cards & Patient Assistance

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