Buy Sinemet (Carbidopa/Levodopa) Online From Medications Canada.

About Sinemet (Carbidopa/Levodopa)

Uses and Benefits of Sinemet (Carbidopa/Levodopa)

Sinemet (Carbidopa/Levodopa) is indicated for the treatment of Parkinson’s disease, post-encephalitic Parkinsonism, and symptomatic Parkinsonism caused by carbon monoxide or manganese exposure. Carbidopa helps patients take lower doses of levodopa by reducing its breakdown outside the brain. Some patients who did not respond well to levodopa alone have improved with Sinemet. This effect is due to carbidopa reducing levodopa breakdown, not a direct effect on the nervous system. Carbidopa does not increase levodopa’s effectiveness but may help reduce nausea and vomiting, allowing for faster dose adjustments.

Ingredients in Sinemet (Carbidopa/Levodopa)

The active ingredients in Sinemet are carbidopa and levodopa. It comes in three strengths: Sinemet 25-100 (25 mg carbidopa, 100 mg levodopa), Sinemet 10-100 (10 mg carbidopa, 100 mg levodopa), and Sinemet 25-250 (25 mg carbidopa, 250 mg levodopa). Inactive ingredients include microcrystalline cellulose, pregelatinized starch, corn starch, and magnesium stearate. Sinemet 10-100 and Sinemet 25-250 also contain FD&C Blue #2. Sinemet 25-100 also contains D&C Yellow #10.

How to Take Sinemet (Carbidopa/Levodopa)?

Follow your doctor’s prescription exactly.

Sinemet (Carbidopa/Levodopa) comes in three strengths: 25-100, 10-100, and 25-250. The usual starting dose is one 25-100 tablet three times a day, providing 75 mg of carbidopa daily. Your doctor may increase the dose by one tablet daily or every other day until you take up to eight tablets per day. If using the 10-100 strength, the starting dose is one tablet three or four times a day. Your doctor may increase the dose until you take two tablets four times a day.

Switching from Levodopa Stop taking levodopa at least 12 hours before starting Sinemet. The starting Sinemet dose should be about 25% of your previous levodopa dose. If you took less than 1,500 mg of levodopa daily, you may start with one 25-100 tablet three or four times a day. If you took more than 1,500 mg daily, you may start with one 25-250 tablet three or four times a day.

Maintenance Dose Your doctor will adjust your dose to get the best response. You should receive at least 70-100 mg of carbidopa daily. If you need more carbidopa, your doctor may switch you to 25-100 tablets. If you need more levodopa, your doctor may switch you to 25-250 tablets. The 25-250 dose may increase by one-half or one tablet daily or every other day, with a maximum of eight tablets per day.

Monitoring Your doctor will monitor you closely when adjusting your dose. Sinemet works faster than levodopa alone, which may cause involuntary movements sooner. If this happens, your doctor may lower your dose. Eyelid spasms (blepharospasm) may be an early sign of taking too much Sinemet.

Other Parkinson’s Medications You can take Sinemet with other Parkinson’s medications, except levodopa without a decarboxylase inhibitor. Your doctor may adjust your dose if needed.

Stopping Sinemet Do not stop or lower your Sinemet dose without medical advice. Stopping suddenly can cause serious problems, including fever and confusion. Your doctor will monitor you closely, especially if you are taking neuroleptics.

Surgery You can continue taking it before surgery as long as you can take fluids and medicine by mouth. If you stop taking the medication temporarily, your doctor will monitor you for symptoms similar to neuroleptic malignant syndrome (NMS). Resume your usual dose as soon as you can take oral medication.

Who Should Not Use Sinemet (Carbidopa/Levodopa)?

Do not use Sinemet (Carbidopa/Levodopa) if you take nonselective monoamine oxidase (MAO) inhibitors. Stop these medications at least 2 weeks before starting Sinemet. You may take Sinemet with an MAO-B inhibitor, such as selegiline, at the recommended dose.

Do not use Sinemet if you are allergic to any of its ingredients. Do not take Sinemet if you have narrow-angle glaucoma.

Side Effects

Common Side Effects:

• Involuntary movements (choreiform, dystonic, or other dyskinesias)
• Nausea
• Dizziness
• Headache
• Dry mouth

Serious Side Effects:

• Irregular heartbeat or changes in blood pressure
• Psychotic symptoms such as hallucinations, delusions, or paranoia
• Severe allergic reactions such as swelling (angioedema), hives, or severe skin reactions
• Gastrointestinal bleeding or duodenal ulcers
• Blood disorders such as anemia, leukopenia, or thrombocytopenia

This is not a complete list of possible side effects. For a complete list, ask your doctor or pharmacist.

Safety Precautions

Before you take the medication, tell your healthcare provider if you: • Take Levodopa—stop at least 12 hours before starting Sinemet • have depression or suicidal thoughts • have severe heart, lung, kidney, liver, or endocrine problems • have a history of heart attack or irregular heartbeat—your doctor should monitor your heart • have or had peptic ulcers—it may increase the risk of GI bleeding

Falling Asleep During Activities Some people taking Sinemet fall asleep suddenly, even while driving. Tell your doctor if you feel unusually sleepy or have fallen asleep suddenly before. If this happens, do not drive or operate machinery. Your doctor may adjust your dose or stop Sinemet.

Risk of Fever and Confusion Stopping or lowering Sinemet too quickly can cause a serious reaction like neuroleptic malignant syndrome (NMS). Symptoms include fever, stiff muscles, confusion, sweating, and a fast heartbeat. Seek medical help if you notice these symptoms.

Other Precautions Your doctor should monitor your liver, kidneys, heart, and blood function. If you have glaucoma, regular eye pressure checks are needed.

Sinemet may cause involuntary movements, hallucinations, or unusual behaviors. Tell your doctor if you notice changes in your thoughts or actions. Some patients develop strong urges, like gambling, spending, or increased sexual urges—report these to your doctor.

People with Parkinson’s disease have a higher risk of melanoma. Get regular skin exams.

Important Information for Patients Take Sinemet on schedule. Do not change your dose or take other Parkinson’s medications without your doctor’s approval.

Symptoms may return before your next dose—tell your doctor if this happens.

Sinemet may turn your saliva, urine, or sweat dark. This is harmless but can stain clothes.

High-protein foods, acidic foods, and iron supplements can affect Sinemet’s absorption. Talk to your doctor about your diet.

Lab Tests Sinemet may affect liver function tests and urine tests. It can cause false-positive or false-negative results for some lab tests, including ketone bodies and glucose in urine. It may also cause false-positive results for pheochromocytoma screening.

Pregnancy and Breastfeeding Tell your doctor if you are pregnant or planning to become pregnant. It is not known if Sinemet is safe during pregnancy. If you are breastfeeding, tell your doctor that levodopa passes into breast milk.

Use in Children and Older Adults Sinimet’s safety and effectiveness in children are not known. Older adults may be more sensitive to side effects. Your doctor will adjust the dose if needed.

Storage Guidelines

Store Sinemet at 25°C (77°F). Short-term exposure to temperatures between 15°C and 30°C (59°F and 86°F) is allowed. Keep Sinemet in a tightly closed, light-resistant container, away from moisture. Protect the medication from direct light. Store in a dry place and keep out of reach of children.

FAQs

How much can I save when purchasing Sinemet from a Canadian pharmacy versus U.S. prices?

Purchasing Sinemet from a Canadian pharmacy can lead to major savings. At Medications Canada, the 25 mg is priced at $221.00 for 200 tablets, compared to about $340.24 in the U.S. You save up to 35%.

How long does it take to receive Sinemet when ordering online?

It takes approximately 2 to 4 weeks for shipping Sinemet after it leaves the pharmacy.

Is a prescription required to buy Sinemet online?

Yes, a valid prescription is required to buy Sinemet online.

What payment options are available for purchasing Sinemet online?

We take payments by personal check, certified check, international money order, and e-check.

What is the refund or return policy for Sinemet bought online?

Pharmaceutical laws and safety rules prevent us from accepting returns or issuing refunds for Sinemet bought online. Always consult your doctor before ordering. Read more.

Is Sinemet available over-the-counter?

Sinemet is not available over the counter because it needs to be used under a doctor’s supervision. Due to the risk of serious side effects, like uncontrolled movements, a valid prescription is required to ensure safe Use.

Reference

• FDA. Sinemet (Carbidopa and Levodopa) Prescribing Information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/017555s072lbl.pdf
• MedlinePlus. Parkinson’s Disease. https://medlineplus.gov/parkinsonsdisease.html
• Drugs.com. Sinemet Prices, Coupons & Patient Assistance. https://www.drugs.com/price-guide/sinemet